بررسی سطوح پلاسمایی محصولات تخریب فیبرینوژنFDP)) وD-dimer در بیماران سیروتیک با و بدون آسیت و ارتباط آن‌ها باMELD-score

    Received: 16 Oct, 2012 Accepted: 22 Dec, 2012      Background & Aims : Liver cirrhosis is associated with coagulation disorders due to decreased synthesis of clotting and inhibitor factors. It has been hypothesized that ascites plays an important role in hyperfibrinolytic state and increased risk of bleeding. We have studied the role of ascites in the hyper fibrinolytic state and relationship between MELD-score and hyper fibrinolytic state in cirrhotic patients .   Materials & Methods : This study was conducted on 82 patients with liver cirrhosis from May 2011 to September 2012. All patients were classified into two groups: with and without ascites. The plasma levels of (FDP) Fibrinogen degradation products and D-dimer were measured, and all patients' MELD-score were calculated. Statistical analyses were carried out to evaluate the correlation of ascites and MELD-score with hyper fibrinolytic state .   Results : There were 47.6% male and 52.4% female patients. Mean age of patients was 51±17. 5 years. 52 (63. 4%) patients have ascites. FDP plasma level in 46(88. 5%) and D-dimer plasma level in 45(86. 5%) of cirrhotic patients with ascites had been increased while FDP plasma level in 6(20%) and D-dimer plasma level in 4 (13. 3 %) of cirrhotic patients without ascites had been increased. The mean of FDP and D-dimer plasma levels in cirrhotic patients with ascites was significantly higher than their levels in patients without ascites (P <0. 001) .   Conclusion : Ascites fluid has an important role in hyperfibrinolytic state of cirrhotic patients.        SOURCE: URMIA MED J 2012: 23(7): 821 ISSN: 1027-3727